Type IIB Orientifolds without Untwisted Tadpoles, and non-BPS D-branes

We discuss the construction of six- and four-dimensional Type IIB orientifolds with vanishing untwisted RR tadpoles, but generically non-zero twisted RR tadpoles. Tadpole cancellation requires the introduction of D-brane systems with zero untwisted RR charge, but non-zero twisted RR charges. We construct explicit models containing branes and antibranes at fixed points of the internal space, or non-BPS branes partially wrapped on it. The models are non-supersymmetric, but are absolutely stable against decay to supersymmetric vacua. For particular values of the compactification radii tachyonic modes may develop, triggering phase transitions between the different types of non-BPS configurations of branes, which we study in detail in a particular example. As an interesting spin-off, we show that the \IT^6/\IZ_4 orientifold without vector structure, previously considered inconsistent due to uncancellable twisted tadpoles, can actually be made consistent by introducing a set of brane-antibrane pairs whose twisted charge cancels the problematic tadpole.Comment: 36 pages, Latex, 4 eps figure

Independent Work Placements As A Getway To The World Of Work

Small to Medium-sized Enterprises (SMEs), a wide range of other languages are used. Every language is an asset. The most commonly spoken languages across enterprises of all sizes in the UK are French, German and Spanish, the ..

Axion interpretation of the PVLAS data?

The PVLAS collaboration has recently reported the observation of a rotation of the polarization plane of light propagating through a transverse static magnetic field. Such an effect can arise from the production of a light, m_A ~ meV, pseudoscalar coupled to two photons with coupling strength g_{A\gamma} ~ 5x10^{-6} GeV^{-1}. Here, we review these experimental findings, discuss how astrophysical and helioscope bounds on this coupling can be evaded, and emphasize some experimental proposals to test the scenario.Comment: 4 pages, 1 figure, jpconf.cls, talk presented at the ninth International Conference on Topics in Astroparticle and Underground Physics, TAUP 2005, Zaragoza, Spain, September 10-14, 200

Parallelization of a Monte Carlo Ray Tracing Algorithm for Channel Modelling in Underwater Wireless Optical Communications

AbstractIn this paper, an algorithm to calculate the underwater wireless optical impulse response is presented. It is based on a modified Monte Carlo Ray Tracing algorithm and takes into account the most significant phenomena of the underwater channel. In order to reduce the simulation time, two parallelization schemes are proposed, one based on a multiprocessor architecture and other based on the use of GPU (Graphics Processing Unit). Several simulation results are presented, including scenario channel simulations and calculation of time computation complexity for each algorithm implementation

On Statistical Modeling of Sequencing Noise in High Depth Data to Assess Tumor Evolution

© 2017, Springer Science+Business Media, LLC, part of Springer Nature. One cause of cancer mortality is tumor evolution to therapy-resistant disease. First line therapy often targets the dominant clone, and drug resistance can emerge from preexisting clones that gain fitness through therapy-induced natural selection. Such mutations may be identified using targeted sequencing assays by analysis of noise in high-depth data. Here, we develop a comprehensive, unbiased model for sequencing error background. We find that noise in sufficiently deep DNA sequencing data can be approximated by aggregating negative binomial distributions. Mutations with frequencies above noise may have prognostic value. We evaluate our model with simulated exponentially expanded populations as well as data from cell line and patient sample dilution experiments, demonstrating its utility in prognosticating tumor progression. Our results may have the potential to identify significant mutations that can cause recurrence. These results are relevant in the pretreatment clinical setting to determine appropriate therapy and prepare for potential recurrence pretreatment

Poincare Recurrences and Topological Diversity

Finite entropy thermal systems undergo Poincare recurrences. In the context of field theory, this implies that at finite temperature, timelike two-point functions will be quasi-periodic. In this note we attempt to reproduce this behavior using the AdS/CFT correspondence by studying the correlator of a massive scalar field in the bulk. We evaluate the correlator by summing over all the SL(2,Z) images of the BTZ spacetime. We show that all the terms in this sum receive large corrections after at certain critical time, and that the result, even if convergent, is not quasi-periodic. We present several arguments indicating that the periodicity will be very difficult to recover without an exact re-summation, and discuss several toy models which illustrate this. Finally, we consider the consequences for the information paradox.Comment: 18 + 8 pages, 5 figures. v2: reference adde

Unitarity, quasi-normal modes and the AdS_3/CFT_2 correspondence

In general, black-hole perturbations are governed by a discrete spectrum of complex eigen-frequencies (quasi-normal modes). This signals the breakdown of unitarity. In asymptotically AdS spaces, this is puzzling because the corresponding CFT is unitary. To address this issue in three dimensions, we replace the BTZ black hole by a wormhole, following a suggestion by Solodukhin [hep-th/0406130]. We solve the wave equation for a massive scalar field and find an equation for the poles of the propagator. This equation yields a rich spectrum of {\em real} eigen-frequencies. We show that the throat of the wormhole is $o(e^{-1/G})$, where $G$ is Newton's constant. Thus, the quantum effects which might produce the wormhole are non-perturbative.Comment: 9 page

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P<0.0001). In particular, twenty-five epigenetic modifiers were found mutated (e.g. ASXL1, TET2, SUZ12, ARID1A, PHF2, CHD8); ASXL1 was the most frequently affected (28.6% of cases). To evaluate the impact of the identified epigenetic mutations at the gene-expression and Histone H3 lysine 27 trimethylation/acetylation levels, we performed additional RNA and pathology tissue-chromatin immunoprecipitation sequencing experiments. The patients displayed enrichment in gene signatures regulated by methylation and modifiable by decitabine administration, shared common H3K27-acetylated regions, and had a set of cell-cycle genes aberrantly up-regulated and marked by promoter acetylation. Collectively, the integration of sequencing data showed the potential of a therapy based on epigenetic agents. Through the adoption of a preclinical BPDCN mouse model, established by CAL-1 cell line xenografting, we demonstrated the efficacy of the combination of the epigenetic drugs 5’-azacytidine and decitabine in controlling disease progression in vivo

Gravitational Approach to Tachyon Matter

We found a gravity solution of p+1 dimensional extended object with SO(p)xSO(9-p) symmetry which has zero pressure and zero dilaton charge. We expect that this object is a residual tachyon dust after tachyon condensation of brane and anti-brane system discussed by Sen, recently. We also discuss the Hawking temperature and some properties of this object.Comment: 14 pages, LaTeX, reference added and typos correcte